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Ping Liu, Yun-Qing Huang, Wen-Jing Cai, Bi-Feng Yuan, and Yu-Qi Feng.Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry. Sanwang Li, Balázs Klencsár, Lieve Balcaen, Filip Cuyckens, Frederic Lynen, and Frank Vanhaecke.High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure. Nicola Gray, Rabiya Zia, Adam King, Vishal C.

Highly Sensitive Quantification Method for Amine Submetabolome Based on AQC-Labeled-LC-Tandem-MS and Multiple Statistical Data Mining: A Potential Cancer Screening Approach.

Qian Zhang, Huarong Xu, Ran Liu, Peng Gao, Xiao Yang, Pei Li, Xiaotong Wang, Yiwen Zhang, Kaishun Bi, Qing Li.

Metabonomic Investigation of Biological Effects of a New Vessel Target Protein tTF-pHLIP in a Mouse Model.

Laifeng Ding, Congcong Zhang, Zhigang Liu, Qingxia Huang, Yinlong Zhang, Suping Li, Guangjun Nie, Huiru Tang, Yulan Wang.

Sensitive Bromine-Labeled Probe D-BPBr for Simultaneous Identification and Quantification of Chiral Amino Acids and Amino-Containing Metabolites Profiling in Human Biofluid by HPLC/MS.

Kexin Shen, Lin Wang, Quan He, Zhe Jin, Weiyi Chen, Cuirong Sun, Yuanjiang Pan.

Metabolic Profiling of Urinary Chiral Amino-Containing Biomarkers for Gastric Cancer Using a Sensitive Chiral Chlorine-Labeled Probe by HPLC-MS/MS.

Rongrong Huang, Kexin Shen, Quan He, Yiqiu Hu, Cuirong Sun, Cheng Guo, Yuanjiang Pan.

Ion-Pairing Chromatography and Amine Derivatization Provide Complementary Approaches for the Targeted LC-MS Analysis of the Polar Metabolome. Grover, Karsten Siems, Francesca Cirulli, Alessandra Berry, Chiara Musillo, Ian D.

Virag Sagi-Kiss, Yufeng Li, Matthew R.This article is cited by 93 publications. With the inclusion of antioxidant and reducing agents, tris(2-carboxyethyl)-phosphine (TCEP) and ascorbic acid, into both extraction solvents and reaction buffers, degradation was significantly decreased, allowing reproducible identification and quantification of amine compounds in large sample sets. The stability of derivatized amines was found to be variable with oxidatively labile derivatives rapidly degrading. Further, with the use of accurate mass, charge state, and retention time, identification of unknown amines is facilitated. With the use of untargeted fragmentation scan functions, such as precursor ion scanning, the loss of the aminoquinoline tag (Amq) can be monitored to identify derivatized species and the use of targeted fragmentation scans, such as multiple reaction monitoring, can be exploited to quantitate amine-containing molecules. Upon collision induced dissociation (CID) in a quadrupole collision cell, all derivatized compounds lose the aminoquinoline tag. Complex mixtures of these amine derivatives can be fractionated and quantified using liquid chromatography–electrospray ionization-mass spectrometry (LC–ESI-MS). Primary and secondary amines, including amino acids, biogenic amines, hormones, neurotransmitters, and plant siderophores, are readily derivatized with 6-aminoquinolyl- N-hydroxysuccinimidyl carbamate using easily performed experimental methodology.